SECOND KEY QUESTION: Since withdrawal discomfort is now readily controlled with various medications, so that an addict can be brought without difficulty to an abstinent state, why doesn’t that solve the problem? Why is relapse so common? Is it because of innate deficiencies in the reward pathway, or because chronic exposure to an opiate has caused irreversible changes? In either case, there may be addicts who can not function normally on their own supply of endorphins but require some opiate (like methadone) to occupy the receptors.

We need to know what triggers relapse in an abstinent ex-addict. Relapse is preceded by craving — an irresistible urge to use, often provoked by an environmental cue related to previous use. A cue such as the sight of injection paraphernalia or of a place to buy heroin on the street can not only evoke craving, but can cause measurable physiologic changes like altered pulse, blood pressure, and galvanic skin responses.

A recent study, by researchers at the National Institute on Drug Abuse, concerns craving for cocaine in former cocaine abusers. The method was PET scan, an imaging procedure that shows which areas in the living human brain are activated by certain stimuli. There are two groups of subjects — people who had never used cocaine, and people who had been cocaine abusers in the past but had not used any in recent months. Two kinds of cue were presented on video tape — a neutral one (such as a pastoral scene), and a cocaine-related one (such as injection equipment). Subjects who had never used cocaine showed no unusual brain activity when exposed to either kind of cue. Subjects who had abused cocaine in the past were not affected at all by a neutral cue; but they responded very differently to a cocaine-related cue. Intense craving was provoked, and specific brain areas lit up on the PET scan — areas in parts of the brain (frontal cortex and amygdala) that are known to be associated with emotional memories and craving.

I tell you about this experiment because it shows clearly that in the subjects with previous heavy exposure to cocaine, certain brain regions had been altered by the chronic use of the addictive drug. And it also shows which brain areas are specifically involved in the craving that leads to relapse. Most important for us, it points the way to future similar research with heroin addicts, using brain imaging techniques — an exciting prospect that was only a dream just a few years ago.

Source:
Neurobiology of Heroin Addiction and of Methadone Treatment
By: Avram Goldstein, M.D.
Professor Emeritus of Pharmacology, Stanford University

@aatod1984
  • Research shows methadone maintenance is more effective when it includes counseling—and even more so with medical or psychosocial services, like employment or family assistance. This is a key piece of #MAT for #OUD. More info: https://lnkd.in/ehYFCRvu 
#PNAP #ProgramNotaPill
  • Quick Reminder - Our committee deadline for #aatod2024 Conference related presentations is fast approaching on Monday, September 18th. We are encouraging you to submit your presentations since it will certainly contribute to an information-packed conference event.
  • #ICYMI, AATOD’s recent “How To” Webinar, Expanding the Use of Mobile Vans, is now available for viewing. Speakers included policy partners from the #DEA, #SAMHSA and #OTPs. 
Access to Full Video ➡️ youtu.be/f0KPRoYE7c8 🎥
  • August 21 is National Fentanyl Prevention and Awareness Day. GET THE FACTS ON #FENTANYL ➡️bit.ly/3OMPZo6.

According to the CDC, an estimated 110,511 people in the U.S. died of drug overdoses and poisonings in 2022, with almost 70 % of those deaths involving synthetic opioids like fentanyl. Only 2 mg of fentanyl is considered a potentially lethal dose. #facingfentanylnow
  • We invite you to join us as we continue to address the #opioid epidemic. 

Save the Date: #aatod2024 Conference
May 18-22, 2024

Location: Planet Hollywood Las Vegas Resort and Casino

Conference Theme: Treating Opioid Use Disorders, So Much More Than Medication

Important Deadlines:
CALL FOR PRESENTATIONS SUBMISSION DEADLINE: SEPTEMBER 18, 2023
EARLY REGISTRATION DEADLINE: JANUARY 31, 2024

For more details ➡️ www.aatodconference.com

This Conference will represent 40 years since our Association convened our first Conference in New York City in 1984 under the aegis of the Northeast Regional Methadone Treatment Coalition.

#aatod2024 Conference will prove to be a landmark event, providing access to current research and policy considerations as our country continues to face challenges with opioid use disorder, especially in an era of dangerous #fentanyl use. #OUD
  • We invite you to join us as we continue to address the #opioid epidemic. 

Save the Date: #aatod2024 Conference
May 18-22, 2024

Location: Planet Hollywood Las Vegas Resort and Casino

Conference Theme: Treating Opioid Use Disorders, So Much More Than Medication

Important Deadlines:
CALL FOR PRESENTATIONS SUBMISSION DEADLINE: SEPTEMBER 18, 2023
EARLY REGISTRATION DEADLINE: JANUARY 31, 2024

For more details ➡️ www.aatodconference.com

This Conference will represent 40 years since our Association convened our first Conference in New York City in 1984 under the aegis of the Northeast Regional Methadone Treatment Coalition.

#aatod2024 Conference will prove to be a landmark event, providing access to current research and policy considerations as our country continues to face challenges with opioid use disorder, especially in an era of dangerous #fentanyl use. #OUD
  • We invite you to join us as we continue to address the #opioid epidemic. 

Save the Date: #aatod2024 Conference
May 18-22, 2024

Location: Planet Hollywood Las Vegas Resort and Casino

Conference Theme: Treating Opioid Use Disorders, So Much More Than Medication

Important Deadlines:
CALL FOR PRESENTATIONS SUBMISSION DEADLINE: SEPTEMBER 18, 2023
EARLY REGISTRATION DEADLINE: JANUARY 31, 2024

For more details ➡️ www.aatodconference.com

This Conference will represent 40 years since our Association convened our first Conference in New York City in 1984 under the aegis of the Northeast Regional Methadone Treatment Coalition.

#aatod2024 Conference will prove to be a landmark event, providing access to current research and policy considerations as our country continues to face challenges with opioid use disorder, especially in an era of dangerous #fentanyl use. #OUD
  • We invite you to join us as we continue to address the #opioid epidemic. 

Save the Date: #aatod2024 Conference
May 18-22, 2024

Location: Planet Hollywood Las Vegas Resort and Casino

Conference Theme: Treating Opioid Use Disorders, So Much More Than Medication

Important Deadlines:
CALL FOR PRESENTATIONS SUBMISSION DEADLINE: SEPTEMBER 18, 2023
EARLY REGISTRATION DEADLINE: JANUARY 31, 2024

For more details ➡️ www.aatodconference.com

This Conference will represent 40 years since our Association convened our first Conference in New York City in 1984 under the aegis of the Northeast Regional Methadone Treatment Coalition.

#aatod2024 Conference will prove to be a landmark event, providing access to current research and policy considerations as our country continues to face challenges with opioid use disorder, especially in an era of dangerous #fentanyl use. #OUD
  • We invite you to join us as we continue to address the #opioid epidemic. 

Save the Date: #aatod2024 Conference
May 18-22, 2024

Location: Planet Hollywood Las Vegas Resort and Casino

Conference Theme: Treating Opioid Use Disorders, So Much More Than Medication

Important Deadlines:
CALL FOR PRESENTATIONS SUBMISSION DEADLINE: SEPTEMBER 18, 2023
EARLY REGISTRATION DEADLINE: JANUARY 31, 2024

For more details ➡️ www.aatodconference.com

This Conference will represent 40 years since our Association convened our first Conference in New York City in 1984 under the aegis of the Northeast Regional Methadone Treatment Coalition.

#aatod2024 Conference will prove to be a landmark event, providing access to current research and policy considerations as our country continues to face challenges with opioid use disorder, especially in an era of dangerous #fentanyl use. #OUD
  • We invite you to join us as we continue to address the #opioid epidemic. 

Save the Date: #aatod2024 Conference
May 18-22, 2024

Location: Planet Hollywood Las Vegas Resort and Casino

Conference Theme: Treating Opioid Use Disorders, So Much More Than Medication

Important Deadlines:
CALL FOR PRESENTATIONS SUBMISSION DEADLINE: SEPTEMBER 18, 2023
EARLY REGISTRATION DEADLINE: JANUARY 31, 2024

For more details ➡️ www.aatodconference.com

This Conference will represent 40 years since our Association convened our first Conference in New York City in 1984 under the aegis of the Northeast Regional Methadone Treatment Coalition.

#aatod2024 Conference will prove to be a landmark event, providing access to current research and policy considerations as our country continues to face challenges with opioid use disorder, especially in an era of dangerous #fentanyl use. #OUD
Research shows methadone maintenance is more effective when it includes counseling—and even more so with medical or psychosocial services, like employment or family assistance. This is a key piece of #MAT for #OUD. More info: https://lnkd.in/ehYFCRvu 
#PNAP #ProgramNotaPill
Research shows methadone maintenance is more effective when it includes counseling—and even more so with medical or psychosocial services, like employment or family assistance. This is a key piece of #MAT for #OUD. More info: https://lnkd.in/ehYFCRvu #PNAP #ProgramNotaPill
1 month ago
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Quick Reminder - Our committee deadline for #aatod2024 Conference related presentations is fast approaching on Monday, September 18th. We are encouraging you to submit your presentations since it will certainly contribute to an information-packed conference event.
1 month ago
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2/10
#ICYMI, AATOD’s recent “How To” Webinar, Expanding the Use of Mobile Vans, is now available for viewing. Speakers included policy partners from the #DEA, #SAMHSA and #OTPs. Access to Full Video ➡️ youtu.be/f0KPRoYE7c8 🎥
1 month ago
View on Instagram |
3/10
August 21 is National Fentanyl Prevention and Awareness Day. GET THE FACTS ON #FENTANYL ➡️bit.ly/3OMPZo6. According to the CDC, an estimated 110,511 people in the U.S. died of drug overdoses and poisonings in 2022, with almost 70 % of those deaths involving synthetic opioids like fentanyl. Only 2 mg of fentanyl is considered a potentially lethal dose. #facingfentanylnow
1 month ago
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4/10
We invite you to join us as we continue to address the #opioid epidemic. 

Save the Date: #aatod2024 Conference
May 18-22, 2024

Location: Planet Hollywood Las Vegas Resort and Casino

Conference Theme: Treating Opioid Use Disorders, So Much More Than Medication

Important Deadlines:
CALL FOR PRESENTATIONS SUBMISSION DEADLINE: SEPTEMBER 18, 2023
EARLY REGISTRATION DEADLINE: JANUARY 31, 2024

For more details ➡️ www.aatodconference.com

This Conference will represent 40 years since our Association convened our first Conference in New York City in 1984 under the aegis of the Northeast Regional Methadone Treatment Coalition.

#aatod2024 Conference will prove to be a landmark event, providing access to current research and policy considerations as our country continues to face challenges with opioid use disorder, especially in an era of dangerous #fentanyl use. #OUD
We invite you to join us as we continue to address the #opioid epidemic. Save the Date: #aatod2024 Conference May 18-22, 2024 Location: Planet Hollywood Las Vegas Resort and Casino Conference Theme: Treating Opioid Use Disorders, So Much More Than Medication Important Deadlines: CALL FOR PRESENTATIONS SUBMISSION DEADLINE: SEPTEMBER 18, 2023 EARLY REGISTRATION DEADLINE: JANUARY 31, 2024 For more details ➡️ www.aatodconference.com This Conference will represent 40 years since our Association convened our first Conference in New York City in 1984 under the aegis of the Northeast Regional Methadone Treatment Coalition. #aatod2024 Conference will prove to be a landmark event, providing access to current research and policy considerations as our country continues to face challenges with opioid use disorder, especially in an era of dangerous #fentanyl use. #OUD
1 month ago
View on Instagram |
5/10
We invite you to join us as we continue to address the #opioid epidemic. 

Save the Date: #aatod2024 Conference
May 18-22, 2024

Location: Planet Hollywood Las Vegas Resort and Casino

Conference Theme: Treating Opioid Use Disorders, So Much More Than Medication

Important Deadlines:
CALL FOR PRESENTATIONS SUBMISSION DEADLINE: SEPTEMBER 18, 2023
EARLY REGISTRATION DEADLINE: JANUARY 31, 2024

For more details ➡️ www.aatodconference.com

This Conference will represent 40 years since our Association convened our first Conference in New York City in 1984 under the aegis of the Northeast Regional Methadone Treatment Coalition.

#aatod2024 Conference will prove to be a landmark event, providing access to current research and policy considerations as our country continues to face challenges with opioid use disorder, especially in an era of dangerous #fentanyl use. #OUD
We invite you to join us as we continue to address the #opioid epidemic. Save the Date: #aatod2024 Conference May 18-22, 2024 Location: Planet Hollywood Las Vegas Resort and Casino Conference Theme: Treating Opioid Use Disorders, So Much More Than Medication Important Deadlines: CALL FOR PRESENTATIONS SUBMISSION DEADLINE: SEPTEMBER 18, 2023 EARLY REGISTRATION DEADLINE: JANUARY 31, 2024 For more details ➡️ www.aatodconference.com This Conference will represent 40 years since our Association convened our first Conference in New York City in 1984 under the aegis of the Northeast Regional Methadone Treatment Coalition. #aatod2024 Conference will prove to be a landmark event, providing access to current research and policy considerations as our country continues to face challenges with opioid use disorder, especially in an era of dangerous #fentanyl use. #OUD
1 month ago
View on Instagram |
6/10
We invite you to join us as we continue to address the #opioid epidemic. 

Save the Date: #aatod2024 Conference
May 18-22, 2024

Location: Planet Hollywood Las Vegas Resort and Casino

Conference Theme: Treating Opioid Use Disorders, So Much More Than Medication

Important Deadlines:
CALL FOR PRESENTATIONS SUBMISSION DEADLINE: SEPTEMBER 18, 2023
EARLY REGISTRATION DEADLINE: JANUARY 31, 2024

For more details ➡️ www.aatodconference.com

This Conference will represent 40 years since our Association convened our first Conference in New York City in 1984 under the aegis of the Northeast Regional Methadone Treatment Coalition.

#aatod2024 Conference will prove to be a landmark event, providing access to current research and policy considerations as our country continues to face challenges with opioid use disorder, especially in an era of dangerous #fentanyl use. #OUD
We invite you to join us as we continue to address the #opioid epidemic. Save the Date: #aatod2024 Conference May 18-22, 2024 Location: Planet Hollywood Las Vegas Resort and Casino Conference Theme: Treating Opioid Use Disorders, So Much More Than Medication Important Deadlines: CALL FOR PRESENTATIONS SUBMISSION DEADLINE: SEPTEMBER 18, 2023 EARLY REGISTRATION DEADLINE: JANUARY 31, 2024 For more details ➡️ www.aatodconference.com This Conference will represent 40 years since our Association convened our first Conference in New York City in 1984 under the aegis of the Northeast Regional Methadone Treatment Coalition. #aatod2024 Conference will prove to be a landmark event, providing access to current research and policy considerations as our country continues to face challenges with opioid use disorder, especially in an era of dangerous #fentanyl use. #OUD
1 month ago
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7/10
We invite you to join us as we continue to address the #opioid epidemic. 

Save the Date: #aatod2024 Conference
May 18-22, 2024

Location: Planet Hollywood Las Vegas Resort and Casino

Conference Theme: Treating Opioid Use Disorders, So Much More Than Medication

Important Deadlines:
CALL FOR PRESENTATIONS SUBMISSION DEADLINE: SEPTEMBER 18, 2023
EARLY REGISTRATION DEADLINE: JANUARY 31, 2024

For more details ➡️ www.aatodconference.com

This Conference will represent 40 years since our Association convened our first Conference in New York City in 1984 under the aegis of the Northeast Regional Methadone Treatment Coalition.

#aatod2024 Conference will prove to be a landmark event, providing access to current research and policy considerations as our country continues to face challenges with opioid use disorder, especially in an era of dangerous #fentanyl use. #OUD
We invite you to join us as we continue to address the #opioid epidemic. Save the Date: #aatod2024 Conference May 18-22, 2024 Location: Planet Hollywood Las Vegas Resort and Casino Conference Theme: Treating Opioid Use Disorders, So Much More Than Medication Important Deadlines: CALL FOR PRESENTATIONS SUBMISSION DEADLINE: SEPTEMBER 18, 2023 EARLY REGISTRATION DEADLINE: JANUARY 31, 2024 For more details ➡️ www.aatodconference.com This Conference will represent 40 years since our Association convened our first Conference in New York City in 1984 under the aegis of the Northeast Regional Methadone Treatment Coalition. #aatod2024 Conference will prove to be a landmark event, providing access to current research and policy considerations as our country continues to face challenges with opioid use disorder, especially in an era of dangerous #fentanyl use. #OUD
1 month ago
View on Instagram |
8/10
We invite you to join us as we continue to address the #opioid epidemic. 

Save the Date: #aatod2024 Conference
May 18-22, 2024

Location: Planet Hollywood Las Vegas Resort and Casino

Conference Theme: Treating Opioid Use Disorders, So Much More Than Medication

Important Deadlines:
CALL FOR PRESENTATIONS SUBMISSION DEADLINE: SEPTEMBER 18, 2023
EARLY REGISTRATION DEADLINE: JANUARY 31, 2024

For more details ➡️ www.aatodconference.com

This Conference will represent 40 years since our Association convened our first Conference in New York City in 1984 under the aegis of the Northeast Regional Methadone Treatment Coalition.

#aatod2024 Conference will prove to be a landmark event, providing access to current research and policy considerations as our country continues to face challenges with opioid use disorder, especially in an era of dangerous #fentanyl use. #OUD
We invite you to join us as we continue to address the #opioid epidemic. Save the Date: #aatod2024 Conference May 18-22, 2024 Location: Planet Hollywood Las Vegas Resort and Casino Conference Theme: Treating Opioid Use Disorders, So Much More Than Medication Important Deadlines: CALL FOR PRESENTATIONS SUBMISSION DEADLINE: SEPTEMBER 18, 2023 EARLY REGISTRATION DEADLINE: JANUARY 31, 2024 For more details ➡️ www.aatodconference.com This Conference will represent 40 years since our Association convened our first Conference in New York City in 1984 under the aegis of the Northeast Regional Methadone Treatment Coalition. #aatod2024 Conference will prove to be a landmark event, providing access to current research and policy considerations as our country continues to face challenges with opioid use disorder, especially in an era of dangerous #fentanyl use. #OUD
1 month ago
View on Instagram |
9/10
We invite you to join us as we continue to address the #opioid epidemic. 

Save the Date: #aatod2024 Conference
May 18-22, 2024

Location: Planet Hollywood Las Vegas Resort and Casino

Conference Theme: Treating Opioid Use Disorders, So Much More Than Medication

Important Deadlines:
CALL FOR PRESENTATIONS SUBMISSION DEADLINE: SEPTEMBER 18, 2023
EARLY REGISTRATION DEADLINE: JANUARY 31, 2024

For more details ➡️ www.aatodconference.com

This Conference will represent 40 years since our Association convened our first Conference in New York City in 1984 under the aegis of the Northeast Regional Methadone Treatment Coalition.

#aatod2024 Conference will prove to be a landmark event, providing access to current research and policy considerations as our country continues to face challenges with opioid use disorder, especially in an era of dangerous #fentanyl use. #OUD
We invite you to join us as we continue to address the #opioid epidemic. Save the Date: #aatod2024 Conference May 18-22, 2024 Location: Planet Hollywood Las Vegas Resort and Casino Conference Theme: Treating Opioid Use Disorders, So Much More Than Medication Important Deadlines: CALL FOR PRESENTATIONS SUBMISSION DEADLINE: SEPTEMBER 18, 2023 EARLY REGISTRATION DEADLINE: JANUARY 31, 2024 For more details ➡️ www.aatodconference.com This Conference will represent 40 years since our Association convened our first Conference in New York City in 1984 under the aegis of the Northeast Regional Methadone Treatment Coalition. #aatod2024 Conference will prove to be a landmark event, providing access to current research and policy considerations as our country continues to face challenges with opioid use disorder, especially in an era of dangerous #fentanyl use. #OUD
1 month ago
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10/10

Join OKATOD, one of AATOD’s state chapters, in Oklahoma City on Oct 12 as they convene their ninth annual OKATOD Conference. This year’s theme is HARM REDUCTION: A TRANSFORMATIVE APPROACH.
Register ➡️ http://bit.ly/461CkkG

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2024 Conference Las Vegas

2024 Conference

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